Molecular Formula | C6H4ClN3 |
Molar Mass | 153.57 |
Density | 1.51±0.1 g/cm3(Predicted) |
Melting Point | 114.0 to 118.0 °C |
Appearance | Solid |
Color | White to Gray to Brown |
pKa | 3.68±0.30(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.713 |
MDL | MFCD07778345 |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | 36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
Hazard Class | IRRITANT |
Introduction | 6-chloroimidazo [1,2-b] pyridazine is a pyridazine compound. Pyridazine is a kind of nitrogen-containing heterocyclic compounds, which is an important chemical intermediate, pyridazine derivatives also have good mesogenic properties as organic liquid crystals, and some pyridazine derivatives are also important dye intermediates. |
preparation | to 2-chloroacetaldehyde (55.1g,386mmol) 6-chloropyridazin-3-amine (5G, 38.6mmol) was added and heated to 100 °c for 5 hours. The reaction mixture was concentrated, suspended in water and extracted with ethyl acetate. The aqueous layer was neutralized with NaHCO3 solution, and the resulting solid was filtered and washed with cold water to give, after drying, 6-chloroimidazo [1,2-b] pyridazine (3G, 51%), is a light brown solid. |